Fda basics webinar abrief overview of risk evaluation and mitigation strategies(rems)

Fda basics webinar abrief overview of risk evaluation and mitigation strategies(rems)FDA Basics Webinar: A Brief Overview of Risk Evaluation and Mitigation Strategies (REMS)

In 2007, a new law that gave FDA many new authorities and responsibilities to enhance drug safety was enacted. It's called the Food and Drug Administration Amendments Act - sometimes called FDAAA - and one of its provisions gave FDA the authority to require a Risk Evaluation and Mitigation Strategy-(REMS) from manufacturers to ensure that the benefits of a drug or biological product outweigh its risks.

A REMs may be required by the FDA as part of the approval of a new product, or for an approved product when new safety information arises. Essentially, a REMS is a safety strategy to manage a known or potential serious risk associated with a medicine and to enable patients to have continued access to such medicines by managing their safe use.

This presentation discussed REMS and how they are used to help ensure that the benefits of certain medicines continue to outweigh their risks.

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Online trading academy toronto star cnn stock market future forexOnline trading academy toronto star cnn stock market future forex

Online trading academy toronto star cnn stock market future forex

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Free mt4forex candlestick pattern identification indicator

Free mt4forex candlestick pattern identification indicatorFree MT4 Forex Candlestick Pattern identification indicator

Free MT4 Candlestick Pattern identification indicator

Imagine having a MT4 Forex Candlestick indicator that automatically identifies the major bullish and bearish Forex candlestick reversal patterns automatically for you.

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Forex-definition and synonyms

Forex-definition and synonymsforex  - definition and synonyms

What are red words?

90% of the time, speakers of English use just 7,500 words in speech and writing. These words appear in red, and are graded with stars. One-star words are frequent, two-star words are more frequent, and three-star words are the most frequent.

The thesaurus of synonyms and related words is fully integrated into the dictionary. Click on the thesaurus category heading under the button in an entry to see the synonyms and related words for that meaning.

noun [ uncountable ] business / ?f?reks /

Momentum-definition and synonyms

Momentum-definition and synonymsmomentum  - definition and synonyms

What are red words?

90% of the time, speakers of English use just 7,500 words in speech and writing. These words appear in red, and are graded with stars. One-star words are frequent, two-star words are more frequent, and three-star words are the most frequent.

The thesaurus of synonyms and related words is fully integrated into the dictionary. Click on the thesaurus category heading under the button in an entry to see the synonyms and related words for that meaning.

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Step up to quality

Step up to qualityStep Up To Quality

Step Up To Quality Guidance Document

The Guidance Document is intended to be used as a resource for programs who are working to achieve, maintain, or increase a star rating. The Guidance Document is divided into three parts:

Part One includes basic information, goals, and history of Step Up To Quality.

Part Two outlines eligibility requirements, registration submission, determining a star rating, annual reporting requirements, the renewal process, and star rating change.

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Documentary collection

Documentary collectionDocumentary Collection

DEFINITION of 'Documentary Collection'

Letter Of Credit

Bill Of Exchange

BREAKING DOWN 'Documentary Collection'

A key document in documentary collections is the bill of exchange or draft, which is a formal demand for payment from the exporter to importer. D/Cs can be classified into two types, depending on when payment is sought by the exporter: 1) documents against payment (D/P), which requires the importer to pay the face amount of the draft at sight, or 2) documents against acceptance (D/A), which requires the importer to pay on a specified future date.

In a D/P collection, the exporter ships the goods and then gives the shipping documents to his or her bank (which is also known as the remitting bank). The bank forwards these documents to the importers bank (known as the collecting bank), which will only release the documents to the importer on receipt of payment for the goods. The collecting bank then remits the funds to the exporters bank for payment to the exporter.

A D/A collection differs from a D/P collection because the exporter extends credit to the importer through a time draft in the latter case. Once the importer signs the time draft which becomes a binding obligation to pay by the due date shown on the draft because of the signed acceptance the documents are released to the importer. The collecting bank contacts the importer on the due date for payment, which upon receipt is remitted to the exporters bank for payment to the exporter.

The exporters risk is obviously higher in the D/A collection process, since the exporter has no control over the goods after the importers acceptance and may not get paid for them.

In terms of risk, D/Cs are much safer than an open account but have fewer safeguards than a letter of credit. since the banks neither guarantee payment nor verify document accuracy and authenticity. These features can be exploited by fraudsters posing as either the exporter or importer. As a result, D/Cs are not recommended for exports to nations that are politically or economically unstable. Overall, because of their lower cost and simple process, D/Cs are best suited for established trade relationships in sound export markets, and for transactions involving ocean shipments rather than air or land shipments which are more difficult to control.

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Forex traders leads

Forex traders leadsForex Traders Leads

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Currency exchange rate widget,currency converter widget

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Install Free USD Currency Exchange Rate Widget!

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Topps appsTOPPS APPS NEWS

Topps® BUNT® 2015 Continues to Revolutionize Baseball Cards

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Crude oil trading

Crude oil tradingYou are here

Crude oil is a naturally occurring petroleum product commonly used in energy production and manufacturing. It is typically purchased with the intent to be refined into everyday uses such as diesel, gasoline, heating oil, jet fuel, plastics, cosmetics, medicines and fertilisers. As such its price has a dramatic impact on the global economy. It is traded in high volumes all around the world.

Learn To Trade Oil - Free Webinars, Ebooks and 1:1 Training at Markets

The price of oil is a critical global economic factor, which means that trading is influenced by political and commercial concerns. In general, higher oil prices tend to undermine economic growth as this increases travel and shipping expenses, which increase inflationary pressures. If the price of oil remains high over a long period, the cost of downstream products like plastics and fertilisers are affected as well.

What this means, from a trader’s point of view, is that when the price of oil is high and has remained high for some time, oil producers take steps to reduce the price. Groups like the Organization of Petroleum Exporting Countries or OPEC agree to production slowdowns, and importers reduce purchases. So a trader has to watch for times when a high oil price hits “ resistance ,” and read the news carefully to see when to go short.

But, having a low oil price for an extended period is also not an unequivocally positive factor for the global economy. When the price of oil remains low for too long, the companies that explore and drill for oil cannot raise the capital they need to find and produce enough of it. Because a sufficient supply of oil is essential to the economic security of all of us, it is critical that these companies be able to continue their work.

So, what happens, when the price remains low for a long time, is that importers step up purchases and groups like OPEC reduce production – they do not care to sell at low prices anyway. Again, the trader has to watch for these moments of “ support floor ,” and act accordingly.

But there are other events that have to be observed when trading oil. Geopolitical insecurity almost always has a direct effect on the price of the commodity. War, or the threat of conflict, will push the price of oil up. Similarly, if there is political instability affecting an important oil producer – and that happens a lot, as many are developing countries – elections or other political changes in these countries can push up the price as well.

The trader also has to be aware of the destabilising effect that shale oil production in the US has had on the global oil price. The industry is still trying to adjust to the vast changes that this trend is imposing on it.

How is oil actually traded?

Crude oil futures are standardized, exchange-traded contracts in which the contract buyer agrees to take delivery, from the seller, a specific quantity of crude oil (eg. 1000 barrels) at a predetermined price on a future delivery date. Forex platforms now provide ways for you to trade into oil futures, without actually having to trade the futures themselves, and thus avoiding the necessity of ultimately taking delivery of the oil which is a concomitant of the futures trade.

In line with the world’s standard, there exist two major classifications of crude oil, and different platforms trade each. US oil is referred to as West Texas Intermediate (WTI), and UK oil . called Brent Blend oil. The WTI is considered light with low sulphur content, is used commonly in US. The light density coupled with less impurities makes WTI oil a sweet crude oil, meaning it has a low density, and is more economical to refine and transport. Typically to demonstrate its worth, it trades higher at a dollar or two to Brent. The Brent Blend although not as light as the WTI is a sweet crude and contains approximately 0.37% sulphur. Being refined in Northwest Europe, it is used in production of petrol and middle distillates.

It is possible to trade both of these crude oils on different forex platforms. Trading crude oil on the forex platform may be somewhat different from trading in other commodities. Some platforms simply trade CFDs in oil, and then you trade the contract just as you would a currency pair. Oil is generally traded against the dollar, as oil futures contracts are always priced in dollars.

You will find, on your forex platform, a trading pair like OIL/USD or sometimes CLD/USD. You can go long or short on this pair, just as you would other pairs.

What does make trading crude oil somewhat different than other pairs is that the market is limited by time on some platforms. Oil trading hours are limited to between 02:00 and 21:00 London time on some platforms, as these platforms offer access to specific buyer/seller contracts and not to CFDs.

Similarly, some platforms use contracts for oil that have expiration dates, and the trader should be aware that holding them for too long will lead to their being rolled over into the new contract price.

For example, at expiry time 12:00 GMT the old contract closing price was at US$35.50 per barrel and the new contract price is trading at US$40.50. At expiry, the old deal will be closed automatically at US$35.50. Any profit or loss will be reflected in the margin and thus in the free balance. You have to give special instruction to the dealer, and so the dealer will open a new deal at a price of $40.50 (the price of the new contract at 12:00 GMT), and place an amount equal to the remaining margin on the old deal, unless you provide other instructions.

So it is very important, when trading oil on your forex platform, to be aware of any restrictions or time limitations that may apply.

But clearly, the ability to gain such easy access to this fantastically liquid and fast-moving world market is a terrific opportunity for traders.

Free forex currency tips

Free forex currency tipsFree FOREX Currency Tips

Forex Markets ot the currency markets are one of the most widely growing markets of the world. Trading activities are increasing day by day to an enormous level. With very high liquidity and trading action the international currency markets are being given more and more attention by traders world wide. More traders on a daily basis speculate in the FOREX futures on the exchanges as well as people come here to hedge their business positions the exporters and the importers.